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To start with, Android users in I-Doser Premium will find themselves enjoying multiple doses of mental stimulations, with more than 100 different binaural brainwave sequences. Feel free to try out interesting audio experiences and freely manage your different sequences through the useful I-Doser Cloud. Have access to your powerful doses whenever you need.
And to make it easier for you to manage and choose the right mental doses, the app also provides a variety of different collections for you to quickly access. Feel free to try out any of the provided doses to experience your complete changes of mindset.
Also, to allow Android users to be more engaged in the doses, I-Doser Premium now provides many powerful voiced guides that allow you to understand the training methods, tutorials, and guided videos on brainwave doses. Understand how they work and come up with ways to improve your states of mind with better setups of doses in I-Doser Premium.
Despite the fact that the app is already a paid mobile app on the Google Play Store, Android users are still required to pay for it to unlock certain doses on their devices, especially new ones. That being the case, with the purchased app, you can only make uses of a limited number of doses and trial versions. So if you want more content, prepare to pay extra for the app.
The current study evaluated the safety profile and preliminary efficacy of PEP02 in combination with 5-FU and LV, in patients with refractory advanced malignancy. Gastrointestinal toxicities and myelosuppression were the major DLTs, which were comparable to those of free irinotecan and PEP02 monotherapy [3, 9]. The MTD (80 mg/m2) of PEP02, in combination with infusion of 5-FU and LV on days 1 and 8 of every-3-week schedule is recommended for the future studies. In a previous study, the MTD of PEP02 monotherapy with a 3-week interval was 120 mg/m2 [3]. The favorable toxicity profiles of PEP02 made it a better agent to combine with other cytotoxic agents. 5-FU/LV in combination with irinotecan was the first line treatment of colorectal cancer, which explains our interest in the evaluation of PEP02 in combination with 5-FU/LV. The dose of weekly 5-FU in this study was fixed as 2000 mg/m2, which mimicked the AIO regimen commonly used in Europe and Asia [10, 11]. The percentage of grade III or above AEs or all treatment-related AEs in the MTD group was lower than that in the overall safety population. For hematologic laboratory parameters, nadir was observed between days 13 and 16 after PEP02 administration; however blood biochemistry was mostly unaffected. These tolerable and manageable hematological and non-hematological toxicities indicated that this combination therapy is feasible for further application.
The DESTROY-trial is a non-randomized prospective phase I trial determining a regimen of choice for patients with non-spine bone and lymph node metastases. A total of 90 patients will be included in three different treatment regimens. They will be offered stereotactic ablative radiotherapy in 5, 3 or 1 fractions. Dose-limiting toxicity will be recorded as primary endpoint. Acute and late toxicity, local response and local recurrence, and progression-free survival are secondary endpoints. Liquid biopsies will be collected throughout the course of this study from the second fractionation schedule on.
The term oligometastatic disease describes an intermediate state of cancer spread between localized disease and widespread metastases. It is the state in which a patient presents with a limited number of synchronous or metachronous metastases, with the primary tumour either controlled or not. Weichselbaum and Hellman theorized that before development of widespread metastases, malignant cells harbour restricted metastatic potential and occupy only a limited number of sites apart from the primary tumour [1]. Theoretically, aggressive metastasis-directed therapy (MDT) during this time could delay the need to start systemic therapies and/or prolong progression-free survival. The concept of oligoprogression refers to the situation of disease progression in a limited number of locations after an initial response to systemic treatment. This situation is getting more common in the setting of highly innovative systemic therapies, where metastasis-directed therapy could eradicate disease that does not respond to these pharmaceuticals and thus delay the need to change systemic therapy [2].
Stereotactic ablative body radiotherapy (SABR) is one of the MDTs that can be offered to patients with oligometastatic or oligoprogressive disease, who often present with minimal or no associated symptoms [3, 4]. SABR is defined as the precise delivery of highly conformal and image-guided hypofractionated external-beam radiotherapy to extracranial tumours, typically in a single or a few fraction (s), with doses at least biologically equivalent to a conventional radical course of treatment [5]. However, since this is a relatively new technique, information on the optimal scheduling is lacking. Even prospective randomized trials on SABR for oligometastatic disease typically allow different fractionation schedules to be used [6]. This is especially true for non-spine bone and lymph node metastases, where the literature is scarce to non-existent and many different schedules are used, even within a single center [7, 8].
A minimum of thirty patients will be included for each dose level. The different treatment regimens and their biological effective doses (BED10Gy) and equivalent dose in 2 Gy per fraction (EQD2Gy) are presented in Table 2. Calculations for BED10Gy and EQD2Gy are made using an alpha/beta ratio of 10 and 2, respectively. An interval of at least 24 weeks from the first patient treatment to the next patient treatment at each dose level will be respected. In the meantime, more patients will be included in the previous dose level, in an effort to establish the secondary endpoints. In case 1 to 5 patients present with DLT at 6 months after SABR, 30 additional patients will be included at the same dose level.
Oligometastatic disease is a state in which prolonged progression-free survival resulting from metastasis-directed therapy may be achievable in a subset of patients. For instance, in the pivotal trial by Ost and colleagues, around 20% of oligometastatic prostate cancer patients remained disease-free at 2-years follow-up after only MDT [14]. The role of SABR in the setting of metastases is still emerging but the early results for LC are promising. Most clinical trials evaluating efficacy and safety of this technique are retrospective. Furthermore, most have included various radiation dosing, and especially for non-spine bone and lymph node metastases the evidence on which fractionation schedule to use, is scarce. A phase III clinical trial is currently underway, which is comparing schemes of single doses of 24 Gy to hypofractionated doses of three 9 Gy fractions for different types of metastases, including non-spine bone and lymph node metastases [15].
For lymph node metastases of various histologies, the use of SABR generates high LC levels of 80% and more, with acceptable toxicity [16, 17]. However; various fractionation schemes are described in the literature, which range between single doses of 16 Gy and higher to schemes of 10 fractions of 5 Gy [16,17,18,19,20,21,22,23].
I-Doser is an application for the playback of proprietary audio content. The developer claims the separately purchasable content aims to simulate specific mental states through the use of binaural beats, some of it is named after various recreational drugs.[1] The I-Doser player has been downloaded millions of times[2] and is based on the audio technology of a GPL-licensed binaural beat generator, SBaGen.[3] The player can be downloaded for free, and includes some sample audio content. Additional audio content can be purchased.
I-Doser is the world's top binaural brainwave, lucid dream, mediation, yoga, chakra, kundalini and simulated experience app! Over a decade in development, YOU have made us the top provider of binaural brain doses for every imaginable mood! The Brain Tuner for your Mind, Body, and Soul.Used by over 10 million people worldwide, this proven, safe, and scientific method of synchronizing your brainwaves can help you achieve a simulated state. I-Doser products are the only sequences that have over an 80% success rate in peer review studies. Covered by Kotaku, LA Weekly, Vice, OWNI, Wired, CNN, Fox News, NBC, Spike TV, ABC, Bay 9 News and many many more. This is the original and only official source of I-Doser brand simulated experiences. Don't be fooled by the cheap imitations out there! We are the REAL DEAL!OVER 100 highly advanced binaural brainwave sequences available and managed through I-Doser Cloud! The ONLY binaural simulator to offer integrated ambient soundscape custom tailored to each and every simulation. This is not "white noise," nature sounds, or meditation music. These are powerfully advanced sequences backed by years of research and development.The ONLY binaural simulator with a Chromatherapy Engine for adding additional visual stimuli to your sequences.The ONLY binaural simulator with a reality check timer for checking if you are dreaming and better control of lucid dream sessions.The ONLY binaural simulator that allows you to SlipStream Doses. You visually design your journey in the easiest way possible. Supports Slide Over (on supported devices) for the most refined dosing experience.The ONLY binaural simulator to offer real-time tuning. Fine tune your experience on the fly for the best results possible! For those DIY or How-To people, this can help you refine an experience.The ONLY binaural simulator to offer integrated powerful voice-guided methods to guarantee success! We put as much research and development into our methods as we do our sequences. Try the Experience Method for great results.The ONLY binaural simulator to offer an integrated HyperSkin Engine that allows you to make the app look and feel exactly how you do.The ONLY binaural simulator to offer an integrated Reality Tuner for remembering and controlling Lucid Dreams.The ONLY binaural simulator to offer dozens of professional guides, tutorials and How-To to make sure you get the most out of your experience.Supports Apple Watch for control over the doses. See where you are in the SlipStream with just a glance! Know when the next dose is arriving and see how much time is left in your journey.Supports Apple Health for tracking your session minutes and earning brain training achievements.I-Doser is the only on-the-go mobile brainwave modification tool based on proven and effective sequencing. All you need is a good quality pair of headphones.Rule #1: Results start with quality. Go with a trusted source! 2b1af7f3a8